Our previous study demonstrated that aqueous extract of PE (AEPE) could alleviate carbon tetrachloride (CCl 4)-induced liver fibrosis in vivo, but the underlying molecular mechanisms are still unclear.The present study was undertaken to clarify the multitarget mechanisms of PE in . Phyllanthus emblica, also known as emblic, [2] [4] emblic myrobalan, [2] myrobalan, [4] Indian gooseberry, [2] [4] Malacca tree, [4] or amla, [4] from the Sanskrit ( malak ), is a deciduous tree of the family Phyllanthaceae. Introduction. After the completion of heating-cooling cycle, both formulations were observed the slight changes in physicochemical properties but were stable without phase separation (data shown in TableC). indicates the significant difference from the control (p<0.05, p<0.001). The following is/are the supplementary data to this article: aSchool of Cosmetic Science, Mae Fah Luang University, Chiang Rai, 57100, Thailand, bPhytocosmetics and Cosmeceuticals Research Group, Mae Fah Luang University, Chiang Rai, 57100, Thailand. India (Maharashtra State, Raigad District): pickles made from fresh fruit. A serial dilution of standard gallic acid and extract were mixed with water, Folin-Ciocalteu reagent, and Na2CO3, respectively. Currently, free radicals are associated with the causes of several disorders, including hyperpigmentation and skin aging. Nattaya Lourith: Methodology, Investigation, Writing-review. Topical gel containing 0.1% extract was a stable and safe formulation. Fig. Phyllanthus emblica or Indian Gooseberry is a species commonly known for its fruit called Amla. REH-62117. The baseline melanin indexes of volunteers included in the mild and moderate aging groups were not different. The sample was separated by a gradient mobile phase consisting of acetonitrile (A) and 3% acetic acid (AcOH) (B). The non-invasive instruments were employed to determine effects of gel application at baseline, and post-application at 14, 28, 42, 56, 70, and 84 days. Amla is also known as Indian Gooseberry. Among mild and moderate aging groups, the retraction times at baseline were significantly different, owing the aging characteristics of volunteers. Table1 presents TPC and invitro assays. (mak kham pom) This shrub, native to tropical Asia and probably India, is 4 to 6 m tall, highly branched and gnarled. Cabanes J., Chazarra S., Garcia-Carmona F. KojicAcid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase. The results indicated that base and PE gels were nonirritating products with MII value of 0. Phyllanthus emblica Gaertn., 1791 L., 1753. ]. Our evidence-based analysis on emblica officinalis features 63 unique . Detailed coverage of invasive species threatening livelihoods and the environment worldwide. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Twenty clinically pertinent factors/observations for percutaneous absorption in humans. Delhi, 1978. It is traditionally consumed after meals. (Family Phyllanthaceae) Emblica officinalis, commonly known as amla, is arguably one of the most important plants in various traditional and folk systems of medicine in India. Almost all parts of the tree i.e., root, bark, leaf, flower, fruit and seed . l-dopa was added into mixture and incubated for 20min. The lightening skin color, the enhanced skin elasticity and hydration, and the reduced skin wrinkles after PE gel application were correlated to younger skin properties. The tree has crooked trunk and spreading branches. Amla Seeds (Emblica officinalis) Packet of 10 Seeds. Appendix ASupplementary data to this article can be found online at https://doi.org/10.1016/j.jtcme.2021.02.004. Phyllanthus emblica L., also known as Indian gooseberry, or Amla belongs to the family Euphorbiaceae. TPC of extract was calculated and expressed as mg of gallic acid equivalent per g of extract (mg GAE/g extract).29 The measurement was performed in triplicate. A medium-sized, deciduous tree, 25 to 33 m tall with diameters of 0.3 to 0.6 m. The crown is large, oval and dense. In Ayurveda, amla is considered to be a potent rejuvenator and immunomodulator effective in stalling . (Fam. Scientific name: Plant family: Common name: Lao name: Phyllanthus emblica L. Phyllanthaceae. It is known for its edible fruit of the same name. | Explore the latest full-text research PDFs, articles, conference papers, preprints and more on PHYLLANTHUS EMBLICA. Emblica officinalis), the Indian gooseberry, or aamla from Sanskrit amalika, is a deciduous tree of the family Phyllanthaceae. Additionally, volunteers in the moderate aging group significantly noted the change in skin color after PE gel application, thereby leading to the greater skin brightening score than base gel in the subjective assessment. Invitro and cellular data were compared using one-way analysis of variance (ANOVA) and the least significant difference test (LSD), whereas clinical efficacy data were analyzed by one-way repeated measures ANOVA and Independent t-test. [8] In Theravada Buddhism, this plant is said to have been used as the tree for achieving enlightenment, or Bodhi, by the twenty first Buddha, named Phussa Buddha. Fruit a capsule, subglobose, dehiscing into 6 cocci, disc enlarged, fleshy, yellowish-green, indehiscent berry. Skin wrinkle (SEw) values determined by Visioscan VC 98 in mild and moderate aging groups at baseline were not different. The fruit contains gibberellins, lupeol, kaempferol-3-O--D-glucoside, quercetin-3-O--D-glucoside, emblicanin A and . The functionality is limited to basic scrolling. According to literature, the aging skin is associated with the loss of skin hydration and elasticity as well as the appearance of skin wrinkles and deep furrows.54 The determination of skin elasticity, wrinkles and hydration in clinical study was performed to investigate the anti-skin aging efficacy of PE gel compared to base gel. Regarding melanogenesis suppression, the activity of amla branch extract, sinapic acid and kojic acid was mediated through suppression of tyrosinase and TRP-2 activities. Randomized, double-blind, placebo-control study was performed in 20 volunteers for 84 consecutive days. A study was undertaken in non-obese type 2 diabetic rats to assess the potential anti-diabetic activities of Emblica via its main active ingredient, ellagic . At the completion of study, the increased ITA was greater when treated with PE gel in both aging groups, but there was no statistical difference. It is known for its edible fruit of the same name. The flowers are greenish-yellow. Phyllanthus niruri is a plant with possible health benefits. Comparative study of herbal plants on the phenolic and flavonoid content, antioxidant activities and toxicity on cells and zebrafish embryo. Wilkes M., Wright C.Y., du Plessis J.L., Reeder A. Fitzpatrick skin type, individual typology angle, and melanin index in an African population: steps toward universally applicable skin photosensitivity assessments. Skin aging is a multifactorial process resulted from intrinsic and extrinsic factors. Sinapic acid, the major constituent, along with other phenolics in extract have reported the benefit effects on human health, including anti-carcinogen and anti-inflammation.34 Accordingly, the biological activities of branch extract against skin aging were performed. The plant is not self-fertile. ex Wall. Free radicals, that are produced by endogenous metabolic processes and exogenous factors, such as sun irradiation and pollution, are largely attributed to a complex cascade of cellular oxidative damage. [5] Its native range is tropical and southern Asia. Hydrogen peroxide is used to cause damage by cell membrane leakage and DNA damage.45 The voucher specimen (PE_BR MFU18) was deposited for further reference at our laboratory herbarium at Mae Fah Luang University, Chiang Rai. The ePub format is best viewed in the iBooks reader. Emblica officinalis) colloquially known as the Indian gooseberry (English), amalaka (Sanskrit), and amla (Hindi) is an important deciduous tree.This plant belongs to the Euphorbiaceae family and was originally native to India but is today found growing in Pakistan, Uzbekistan, Srilanka, Southeast Asia China, and Malaysia (Krishnaveni and Mirunalini, 2010). 5.00 - 270.00. 695012, Copyright document.write(new Date().getFullYear()); All rights reserved | State Medicinal Plants Board (SMPB), Kerala Colorlib. Phyllanthus, very large genus of flowering trees, shrubs, and herbs of the spurge family (Euphorbiaceae) that contains among its 650 species some of ornamental value and others with interesting botanical adaptations. Generating an ePub file may take a long time, please be patient. NCBI BLAST name: eudicots Rank: species Genetic code: Translation table 1 (Standard) Mitochondrial genetic code: Translation table 1 (Standard) The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Botanical name: Phyllanthus emblica Family: Phyllanthaceae (Amla family) Synonyms: Emblica officinalis. Lourith N., Kanlayavattanakul M., Chaikul P., Chansriniyom C., Bunwatcharaphansakun P. Miliauskas G., Venskutonis P.R., van Beek T.A. The strong correlation between ITA and melanin indexes have been reported to assess the skin pigmentation.52 The greater ITA and less melanin indexes than baseline after application of PE gel in both mild and moderate aging groups indicated the lightening skin color. Compared to baseline, PE gel significantly shortened the retraction times, resulting in the enhanced skin elasticity after 14 (p=0.036) and 70 (p=0.019) days of application in the mild and moderate aging groups, respectively. Indarbela quadrinotata (bark eating caterpillar), Ceratocystis paradoxa (black rot of pineapple), Lasiodiplodia theobromae (diplodia pod rot of cocoa), Penicillium funiculosum (black spot of pineapple), Rotylenchulus reniformis (reniform nematode), Syncephalastrum racemosum (black soft rot of Indian gooseberry), Alternaria alternata (alternaria leaf spot), Euproctis fraterna (coffee hairy caterpillar), Gibberella acuminata (stalk rot of maize), Gibberella intricans (damping-off of safflower), Rastrococcus invadens (fruit tree mealybug). Emblica officinalis) colloquially known as the Indian gooseberry (English), amalaka (Sanskrit), and amla (Hindi) is an important deciduous tree.. Is Phyllanthus Emblica the same as Emblica officinalis? Amla undeniably a powerhouse of nutrients. UPLC analysis was performed on an ACQUITY H-Class system equipped with an ACQUITY UPLC PDA e detector using a BEH C18 1.7m column (2.1100mm). Phyllanthus emblica L. (amla), a medicinal plant in family Phyllanthaceae, has generally been cultivated in tropical and subtropical countries, including China, . Family: Phyllanthaceae. Ships from and sold by wiccanherbmaster. Slotkin T.A., Seidler F.J. Antimitotic and cytotoxic effects of theophylline in MDA-MB-231 human breast cancer cells. Thrissur Dt. Cambridge: The University Press, 1951. xi, 237 p. The Far Eastern Quarterly, 11(3), 408-410. emblica [16] 3.4. Send Inquiry. Administration of the fresh juice of the fruit at a dose of 5 ml/kg per rabbit per day for 60 days lowered serum cholesterol, triglycerides, phospholipids and low-density lipoprotein levels by 82%, 66%, 77% and 90%, respectively. 15.2.2 Phyllanthus emblica L. or Emblica officinalis Gaertn. Indian Gooseberry, Emblic Myrobalan, Amla, Amalaki, Amloki. Emblica officinalis), commonly known as Indian gooseberry or amla, family Euphorbiaceae, is an important herbal drug used in unani (Graceo - arab) and ayurvedic systems of medicine. The fruit is up to 26mm (1.0in) in diameter, and, while the fruit of wild plants weigh approximately 5.5g (0.19oz), cultivated fruits average 28.4g (1.00oz) to 56g (2.0oz)[6]. The absorbance was measured. Antioxidant, one of several strategies, can deactivate and slow down the damaging reactions induced by free radicals.46 The ability of extract for radical scavenging, which was in agreement with invitro assays, may be attributed to phenolic acids.29,37,47 Vitamin C, a known antioxidant, is mediated activity by reacting with aqueous peroxyl radicals and restoring the antioxidant properties of vitamin E.48. Amla finds uses in many medicinal and cosmetic products, especially those for hair such as hair oils and tonics. Intermediate shoots up to 20 cm long, solitary or fascicled, resembling pinnate leaves but usually floriferous towards the base, falling as a unit; short shoots not strongly developed. The taste of Indian emblic is sour, bitter and astringent, and it is quite fibrous. Twenty healthy Thai volunteers aged 2550 years old showing mild to moderate clinical signs of skin aging with no existing skin conditions and history of allergic reactions were screened to enroll according to the inclusion and exclusion criteria. Phyllanthus emblica is rich in polyphenols and hydrolysable tannin derived compounds that act as antioxidants [22, 32].Well-studied examples include ellagic acid, gallic acid, and chebulagic acid [39-41].These and other tannins from Phyllanthus emblica have been demonstrated to prevent mutagenesis and lipid peroxidation in response to carcinogens and reactive oxygen species []. Partial extraction and identification of phenolics in Amla (. Puxvadee Chaikul, Mayuree Kanlayavattanakul, [], and Nattaya Lourith. Indian gooseberry (Phyllanthus emblica) is regarded as a minor environmental weed in the Northern Territory and as a "sleeper weed" or . Botanic Name Phyllanthus emblica Family Euphorbiaceae English Name Indian gooseberry Malayalam Name Nelli Hindi Name Amla Sanskrit Name Dhatri Habit Tree Description Medium trees. The content on this site is provided and maintained by Mr. Freedman. Adetailed analysis of hydrogen peroxide-induced cell death in primary neuronal culture. The tree habit of the family is represented by Phyllanthus emblica (Amla), Bischofia javanica, Putranjiva roxburghii, etc. Hindi: Aonla. The clinically relevant improvement of skin elasticity and wrinkles were associated with the strong antioxidant and the MMP inhibitory activities of extract invitro and cellular assays. Phyllanthus emblica is highly nutritious . The skin elasticity analyzed by Dermalab USB elasticity probe measures the retraction time after skin stretched by pressure within the vacuum chamber in the device.53 The improved skin elasticity corresponds to the shorter retraction time. Gao L., Kang H., Li Y. Phyllanthus emblica L. (amla), a medicinal plant in family Phyllanthaceae, has generally been cultivated in tropical and subtropical countries, including China, India, Sri Lanka, and Thailand.1 It has been used for treatment of illnesses in traditional medicines, including Indian traditional healthcare system, Tibetan medicine, Sri Lankan medicine, Chinese herbal medicine, and Thai medicinal system.2 Amla demonstrates several biological activities, including antioxidant,3 anti-cancer activity,4,5 anti-diabetic activity,6 anti-inflammatory activity,7,8 anti-microbial activity,9 treatment of gastric ailments,10,11 adaptogenic activity,3 rejuvenating,1,12 and promoting health and longevity13,14 (details of each activity shown in TableA). During study, any skin treatment on treated areas was prohibited as well as smoking and liquor drinking. Amalaki can be used in the effective treatment of diseases like Diabetes, Fever, Anaemia, Jaundice, Bleeding disorders, Hiccough, Arthritis, etc. Screening of radical scavenging activity of some medicinal and aromatic plant extracts. The flowers are pollinated by Bees. , Antioxidant activity assay in human skin fibroblasts treated with solvent control (ctr), H, MMP-2 inhibitory activity in human skin fibroblasts treated with solvent control (ctr), amla branch extract (PE), sinapic acid (SiA), and vitamin C (VC) at 0.1mg/mL: (a) zymogram, and (b) inhibition of MMP-2 activity. The separation conditions were optimized, and the polyphenol content, polyphenol components, antioxidant activity . Male and female flowers are carried separately on the same branch. The zymographic bands were determined with the Bio-Rad Gel Doc Imaging System. According to Fitzpatrick skin type, the skin color of volunteers was classified as skin type III.52 After application of base and PE gels, a decrease in melanin indexes was observed in the mild and moderate aging groups. Pillai S., Oresajo C., Hayward J. Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation-induced matrix degradationa review. indicates the significant difference from the control (p<0.05, p<0.001). Of all the medicinal plants, Phyllanthus emblica, commonly called Indian gooseberry or Amla (Aamvla), a member of the family Phyllanthaceae; a native of Indian subcontinent is known for its wide range of medicinal uses. In the atapacatka, Buddhas knowledge is described in a poetic simile: O Bhagavan, the entire origination of all types of phenomena throughout time is within the range of your mind, like an ambalan fruit in the palm of your hand[7], Half an amalaka fruit was the final gift to the Buddhist sangha by the great Indian emperor Ashoka. Browse 2,939 phyllanthus emblica stock photos and images available, or search for amla to find more great stock photos and pictures. The tested skin was evaluated by Chromameter CR 400, Dermalab USB, Mexameter MX 18, Corneometer CM 825, and Visioscan VC 98. The record derives from WCSP (data supplied on 2012-03-23) which reports it as an accepted name (record 153790) with original publication details: Sp. Among several classes of MMPs, MMP-2 takes its role in cleavage of dermal extracellular matrices, including basement membrane glycoproteins and proteoglycans.23 As shown in Fig. Clinical evidence of effects of, https://doi.org/10.1016/j.jtcme.2021.02.004, Total phenolic content (mg GAE/g extract). Major host of: Boeremia exigua var. Emblica officinalis (Amla) is an ayurvedic herb which has all parts, including the fruits, used for preventative and therapeutic purposes. Its native range is tropical and southern Asia. The cell viabilities of 0.01mg/mL extract, sinapic acid, and vitamin C were 93.240.88, 95.896.52, and 93.484.33%, respectively, which were comparable to solvent control. After 24h incubation, all volunteers, and irregular pigmentation were the major bioactive components in extract time.29! 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